I-China Supply Sarms Raw Sr9009 Stenabolic API

I-REV-ERBα kanye ne-REV-ERBβ ama-nuclear receptors ayizicindezeli ze-transcriptional ezixhumanisa isigqi se-circadian nezindlela ze-metabolic ngendlela encike ku-heme.I-SR9009 iyi-agonist ye-REV-ERB ekhulisa ukucindezelwa okuyisisekelo kwezakhi zofuzo ezilawulwa yi-REV-ERBα kanye ne-REV-ERBβ ngamavelu e-IC50 we-670 kanye ne-800 nM, ngokulandelanayo.1Ngokuvula i-REV-ERB, i-SR9009 iboniswe ukuthi yehlisa umsebenzi we-circadian locomotor phakathi nesigaba sobumnyama futhi iguqule iphethini yokubonisa yezakhi zofuzo zewashi eliyinhloko ku-hypothalami yamagundane.1Iphethini ye-circadian yokuvezwa kohlu lwezakhi zofuzo ze-metabolic esibindini, izicubu zamathambo kanye nezicubu ze-adipose nazo zaboniswa ukuthi zishintshiwe kumagundane avezwe ku-SR9009, okuholela ekusetshenzisweni kwamandla okwandayo. I-SR9009 (i-ip izikhathi ezimbili ngosuku izinsuku ezingu-30) kubikwe ukuthi ibonisa ukuncipha kwesisindo samafutha kanye ne-dyslipidemia ethuthukisiwe kanye ne-hyperglycemia.1

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