Umjovo we-Adipotide 2mg

I-Adipotide (eyaziwa nangokuthi i-FTPP noma i-proapototic peptide) ibulala amangqamuzana amafutha, alula futhi alula, ngokukhomba ukunikezwa kwegazi kulawo maseli.Kuyathakazelisa ukuthi i-adipotide iyakwazi ukubona imithambo yegazi emangqamuzaneni amafutha avela emithanjeni yegazi kuwo wonke umzimba futhi ngenxa yalokho ikhetha kakhulu.Ucwaningo ezinkawini lubonisa ukuthi i-adipotide ayibangeli nje ukuncipha kwesisindo kuphela, empeleni ikhuphula ukuzwela kwe-insulin futhi isuse eminye yemiphumela yohlobo 2 lwesifo sikashukela.

Ukusetshenziswa Komkhiqizo: Lo MKHIQIZO UHLOSELWE NJENGOMTHETHO WEKHEMIKHARI KUPHELA.Lokhu kuqokwa kuvumela ukusetshenziswa kwamakhemikhali ocwaningo kuphela ekuhlolweni kwe-in vitro kanye nokuhlolwa kwelabhorethri kuphela.Yonke imininingwane yomkhiqizo etholakalayo kule webhusayithi ingeyezinjongo zokufundisa kuphela.Ukwethulwa komzimba kwanoma yiluphi uhlobo kubantu noma ezilwaneni kwenqatshelwe ngokuphelele ngumthetho.Lo mkhiqizo kufanele uphathwe kuphela ochwepheshe abanelayisensi, abaqeqeshiwe.Lo mkhiqizo awusona isidakamizwa, ukudla, noma izimonyo futhi akufanele ubhalwe kabi, usetshenziswe kabi noma ulahlwe njengesidakamizwa, ukudla noma izimonyo.

Ukulandelana: Cys-Lys-Gly-Gly-Arg-Ala-Lys-Asp-Cys—Gly-Gly–(Lys-Leu-Ala-Lys-Leu-Ala-Ls)2
I-Molecular Formula: C152H252N44O42
Isisindo samangqamuzana: 2611.41 g/mol

I-Adipotide yasungulwa futhi yafakwa ezivivinyweni zomtholampilo zesigaba I ngo-2011 ukuze kuphenywe amandla ayo okubulala amangqamuzana amafutha.Ukuhlolwa kwezinkawu ze-rhesus kwembula ukuthi i-adipotide ibangela i-apoptosis ehlosiwe emithanjeni yegazi yezicubu ezimhlophe ze-adipose (amafutha).Ngaphandle kokunikezwa kwegazi, amangqamuzana amafutha avele afa.Umphumela waba ukwehla kwesisindo esisheshayo, ukwehla ngokushesha kwe-body mass index (BMI), kanye nezici ezithuthukisiwe zokumelana ne-insulin.Kuyathakazelisa ukuthi ukwelashwa nge-adipotide kanye nokulahlekelwa kwamafutha okwalandela akugcini nje ukuthuthukisa isisindo, kodwa empeleni kube nomthelela ekushintsheni ekuziphatheni kokudla.Izinkawu ezalahlekelwa isisindo nge-adipotide nazo zibonise ukwehla kokusetshenziswa kokudla[1].

A. Amaphesenti okuncipha kwesisindo emaqenjini okulawula (okuluhlaza okwesibhakabhaka) uma kuqhathaniswa nalawo aphathwa nge-adipotide (imithamo emibili ehlukene, eboniswa ngokubomvu)
B. Ukwehliswa kwamaphesenti ku-BMI (ukulawula ngokumelene nokwelashwa)

A. Ibonisa ushintsho ezidingweni ze-insulin (indawo engaphansi kwejika) yamaqembu aphathwayo (okubomvu) kanye nokulawula (okuluhlaza okwesibhakabhaka).I-AUC ibalwe kusukela ekuhlolweni kwe-IVGTT.
B. Ibonisa inkomba ye-insulinogenic yangaphambi nangemuva kwamaqembu okwelashwa (okubomvu) kanye nokulawula (okuluhlaza okwesibhakabhaka).Amaqembu alashiwe akhombisa ukwehla okukhulu kokukhiqizwa kwe-insulin.
C. Shintsha ekusetshenzisweni kwamabhisikidi emaqenjini aphathwayo (okubomvu) kanye nokulawula (okuluhlaza okwesibhakabhaka).

Ukuqondiswa kwe-adipotide emithanjeni yegazi enikezela ngamaseli amafutha kungase kulamule isamukeli samaprotheni esibizwa ngokuthi i-prohibitin.I-Prohibitin iyiphrotheni ye-membrane engatholakala kuphela emithanjeni yegazi ekhonza amafutha amhlophe namangqamuzana omdlavuza.Kuye kwaboniswa ukuthi i-adipotide ihlotshaniswa naleli phrotheni[2].Uma kuvela ukuthi i-prohibitin itholakala kuphela ku-fat vasculature kanye nezicubu zomdlavuza, khona-ke ukuhlolwa kwe-adipotide kuzoba nesibopho sokukhomba inhloso eqondene namafutha engasetshenziswa hhayi nje ngezinjongo zokwelapha, kodwa futhi ngezinjongo zokuxilonga.