SR9009 amaphilisi 100 amaphilisi/ibhodlela

Igama Lomkhiqizo:I-SR9009

Isikhala: 10 mg/iphilisi amaphilisi ayi-100/ibhodlela

Inani:$80/ibhodlela

I-MOQ: ibhodlela elingu-1

Ilebhu: I-LianFu Bio

Ukuchazwa komkhiqizo

I-SR9009, i-REV-ERBi-agonist, kwandisa ukucindezelwa okuyisisekelo kwezakhi zofuzo ezilawulwa yi-REV-ERBα/ERBβ (IC50: 670/800 nM).Ngokusebenzisa i-REV-ERB, i-SR9009 inganciphisa umsebenzi we-circadian locomotor phakathi nesigaba sobumnyama futhi iguqule iphethini yokubonisa yezakhi zofuzo zewashi eliyinhloko ku-hypothalami yamagundane.Iphethini ye-circadian yokuvezwa kohlu lwezakhi zofuzo ze-metabolic esibindini, izicubu zamathambo, kanye nezicubu ze-adipose nayo yashintshwa kumagundane avezwe ku-SR9009, okubangele ukwanda kwezindleko zamandla.

I-SR9009 (100 mg/kg, ip, ibhidi, izinsuku ezingama-30) ingenzekaukunciphisa fat massfuthi ngokuphawulekayongcono i-dyslipidemiafuthii-hyperglycemia.