Impushana eluhlaza yezokwelapha i-MK-677
Incazelo Yomkhiqizo
| Inombolo ye-CAS | 159752-10-0 |
| Ukubukeka | impushana |
| Amagama Amakhemikhali | Ibutamoren;I-CHEMBL13817;S1151_Selleck;I-UNII-GJ0EGN38UL;159634-47-6;MK-0677; |
| I-Molecular Formula | I-C27H36N4O5S |
| Isisindo samangqamuzana | 528.66354 g/mol |
I-MK-677
I-MK-677, eyaziwa nangokuthi i-Ibutamoren, i-SARM yomlomo engeyona i-steroidal (i-modulator ye-androgen receptor ekhethiwe) evame ukusetshenziselwa injongo yokwandisa amazinga e-hormone okukhula emzimbeni.Isithako esisebenzayo ku-MK-677 iyinhlanganisela yamakhemikhali eyaziwa ngokuthi i-Ibutamoren Mesylate.
I-Ibutamoren Mesylate isebenza ngokuvula i-ghrelin receptor, enesibopho sokugqugquzela ukukhiqizwa kwe-hormone yokukhula.I-agonist ekhetha kakhulu, okusho ukuthi iqondise ngokuqondile futhi ivule i-ghrelin receptor, okuholela ekukhuleni kwe-hormone yokukhula.
Ucwaningo luye lwabonisa ukuthi i-MK-677 ingakhuphula ngokuphumelelayo amazinga e-hormone okukhula ngokuphindaphinda okuningi, okuholela ekuthuthukisweni kwesisindo somzimba, ukunciphisa amafutha omzimba, ukuthuthukiswa kwamathambo, kanye nekhwalithi yokulala ethuthukisiwe.Kuphinde kucatshangelwe ukuthi kunezindawo zokulwa nokuguga, njengoba amazinga e-hormone okukhula aphakeme ahlotshaniswa nenani elinciphile lokuguga kanye nokuphila isikhathi eside okwandisiwe.
Khulisa izinga le-hormone yokukhula.I-non-peptide oral growth hormone ikhuthaza ukukhululwa kwe-GH ngokusebenzisa ama-receptors ku-pituitary gland kanye ne-hypothalamus, ehlukile ku-hormone yokukhula ekhulula ama-hormone receptors.I-MK-677 iyi-hormone yokukhula yomlomo ephumelelayo, elingisa umphumela we-GH ekukhuthazeni amahomoni angapheli.Kuye kwaboniswa ukwandisa ukukhululwa nokukhiqiza ukukhula okuqhubekayo kwama-hormone e-plasma, kuhlanganise ne-hormone yokukhula ne-IGF-1, kodwa ayithinti amazinga e-Cortisol.
Njenganoma yimuphi umuthi omusha noma isithasiselo, kubalulekile ukubonisana nochwepheshe bezempilo abaqeqeshiwe ngaphambi kokusebenzisa i-MK-677.
Sengiphetha, i-MK-677 iyisengezo esingase siphumelele ekukhuliseni amazinga e-hormone okukhula kanye nokukhuthaza impilo nempilo yonke jikelele.Nokho, ucwaningo olwengeziwe luyadingeka ukuze kutholwe ukuphepha nokusebenza kwayo kwesikhathi eside, kanye nokuqonda ngokugcwele umthelela wayo emzimbeni womuntu.Njengenjwayelo, kubalulekile ukuqhubeka ngokuqapha lapho usebenzisa noma yisiphi isithasiselo esisha futhi uthintane nochwepheshe bezempilo ngaphambi kokuqala uhlobo olusha lomuthi.
