I-coenzyme encane enomlingo egcina imizimba yethu inyakaza.Nansi indlela i-NAD+ esebenza ngayo nokuthi kungani abantu abaningi beyibona njengendlela yokulwa nokuguga.
Njengoba imakethe yokunqanda ukuguga ikhula ngesivinini eminyakeni yamuva nje, ososayensi bebelokhu befuna noma yiziphi izinhlanganisela ezinganciphisa noma zihlehlise imiphumela yokuguga.Ngokuvamile izixazululo zabo zilele ekutholeni izinto ezishintshayo njengoba sikhula, futhi enye yalezi ezibaluleke kakhulu kube yi-NAD+.Lokhu kuvezwe enanini elikhulayo lezithako ezilwa nokuguga ezifuna ukuthuthukisa impilo ende - kodwa uma usuklebhula ngaphansi kwe-hype kukhona yini ongakujabulela ngempela?Nakhu ukuthi iyini i-NAD+, ukuthi isebenza kanjani nokuthi kungani ibaluleke kangaka emzimbeni wakho nempilo yakho.
Yini i-NAD+?
Njengoba sikhula, imizimba yethu ilahlekelwa ezinye izinto nama-molecule okungaba okubalulekile ekusigcineni sibasha.Enye yazo i-nicotinamide adenine dinucleotide, eyaziwa kangcono nge-NAD+.
Ososayensi baqala ukubheka ubukhona be-NAD+ emuva ngo-1906. Kusukela lapho, ukuqonda kwethu ngayo kuye kwakhula kancane kancane.Kutholwe kanzima emsebenzini kumaseli abantu, izilwane, izitshalo kanye nemvubelo egcina yonke into ihamba kahle.
I-NAD+ iyi-coenzyme ebalulekile engatholakala kuwo wonke amaseli emzimbeni wakho.Isebenza imisebenzi emibili eyinhloko - ukuguqula izakhi zibe amandla futhi ingumdlali obalulekile enqubweni ye-metabolic, esebenza njengomsizi omncane onobungane ekulawuleni eminye imisebenzi yeselula.
Isebenza ngokuphumelelayo njengesithuthi esincane esihambisa ama-electron ukusuka kwelinye i-molecule ukuya kwelinye ukuze enze zonke izinhlobo zokusabela nezinqubo.Eceleni kwenye i-molecule, i-NADH, ibamba iqhaza ekuphenduleni okuningi okukhiqiza amandla ngaphakathi kwamaseli ethu.Kuyasiza futhi ukulawula isigqi sethu se-circadian esilawula umjikelezo wethu wokulala/wokuvuka.
Yatholwa okokuqala ngo-1906 nguHarden and Youngnjengengxenye yokuthuthukisa izinga lokuvutshelwa kotshwala ezikhishwe imvubelo.Kusukela ngaleso sikhathi, ukuqonda kwethu kuye kwakhula kakhulu, futhi kuye kwasetshenziswa ekulweni nezifo eziningi.
Kungani i-NAD+ ibalulekile
I-NAD+ inika amandla, noma isibaseli, samanye ama-molecule asiza umzimba ukuthi usebenze kahle kakhulu.Uma amazinga ehla, imisebenzi yanoma yimaphi ama-enzyme ancike ku-NAD (H) ku-phosphorylation oxidative, umjikelezo we-TCA, kanye ne-glycolysis iyavinjelwa.
Lokhu kubangela ukukhiqizwa kwe-ATP okuphansi.Kungase futhi kuthinte amazinga e-PARP nama-sirtuin futhi kuholele ekungasebenzini kwezindlela ezithile zamangqamuzana ezansi nomfula ezidlala indima ekulungiseni i-DNA.
Ngamanye amazwi, ngaphandle kwawo umzimba wethu awusebenzi ngendlela obungenza ngayo, awusebenzi kahle ekuzilungiseni futhi uholela ekuhambeni kancane kwezinga lokugayeka kokudla emzimbeni.Ngaphandle kwe-NAD+ esebenza njengetekisi elincane elibalulekile, amaseli akho azokhiqiza amandla amancane umzimba awadingayo ukuze uphile futhi wenze imisebenzi yawo.
Ukubaluleka kwe-NAD+, ngakho-ke, akuveli kunoma yisiphi isithako esiwumlingo, kodwa ikhono layo lokusiza amanye ama-molecule anenzuzo enze imisebenzi yawo.Ukube besibheka umzimba njengeqembu lebhola likanobhutshuzwayo, i-NAD+ izoba ngumdlali wasesiswini ophakathi, owenza ama-tackles futhi ehlinzeka ngokuphatha okusiza abagadli babeke ibhola enethini.
Akunabukhazikhazi, akukhona ukubukisa kodwa ngaphandle kwayo, wonke umsebenzi uyahlukana.Lawo ma-molecule abalulekile ekulungiseni amangqamuzana, ukuthuthukisa imetabolism yethu kanye nokulawula imisebenzi yezinto eziphilayo.Ngaphandle kwalo singathola ainani lezinkinga zempilo.
Izinzuzo zengqondo zokwelashwa kwe-NAD+
Esinye sezimpawu zokuguga ukulahlekelwa ukusebenza kwengqondo.Ujwayele ukukhohlwa izinto, ube nenkinga yokugxilisa ingqondo, futhi uzwe sengathi ubuchopho bakho buguqubele noma kunenkungu.Ukwelashwa kwe-NAD kuthatha indawo ye-coenzyme edingekayo ukunciphisa noma ukumisa ukuqhubeka kwalokhu kuncipha.Uzoba:
- Ukwanda kokucaca kwengqondo
- Inkumbulo engcono
- Ukugxila okuphezulu
- Imizwa ethuthukisiwe
- Amakhono angcono okuxazulula izinkinga
Ukuthuthukiswa kokusebenza kobuchopho okuthola ekwelashweni kwe-NAD kungakusiza nokuba ulwe nemizabalazo engokwengqondo engapheli njengokucindezeleka, ukukhathazeka, nokunye ukuphazamiseka kwemizwelo.
Izinzuzo ezingokomzimba zokwelashwa kwe-NAD+
I-NAD ngezinye izikhathi ibizwa ngokuthi “i-molecule yomsizi” ngoba ibopha namanye ama-enzyme futhi iwasize enze umsebenzi wawo kangcono.Okwenzeka kumaseli akho kwenza umehluko omkhulu endleleni obukeka ngayo futhi uzizwe ngayo.Uhlu lwezinzuzo zomzimba ezivela ekwelashweni kwe-NAD lude, futhi noma iyiphi yalezi zithuthukisi ingashintsha impilo yakho ibe ngcono.
- Ithuthukisa impilo yenhliziyo nemithambo yegazi
- Inyusa amandla
- Yandisa imetabolism
- Yehlisa ukuvuvukala
- Isheshisa ukululama ekulimaleni
- Yehlisa ubuhlungu
- Ilola amehlo
- Ithuthukisa ukuzwa
- Yehlisa ukulangazelela izinto eziyingozi
- Yehlisa izimpawu zokuhoxa
- Isiza ukunciphisa umzimba
- Ivikela izinzwa
- Inciphisa inqubo yokuguga
Ngokusobala, izinzuzo zokwelashwa kwe-NAD zimi ekuthuthukiseni ngendlela ephawulekayo impilo yakho yonke kanye nokuphila kahle, ngisho nokwenza ngcono izimpawu zezinye izifo ezimbi kakhulu.
Izifundokhombisa ukuthi ukwelashwa kwe-NAD kunganciphisa izimpawu zesifo i-Alzheimer's.Nakuba imbangela yangempela yesifo i-Alzheimer iseyimpicabadala, siyazi ukuthi ihlanganisa ukufa kwamangqamuzana kanye nokungasebenzi kahle kwe-mitochondrial, kokubili i-NAD ekhuluma ngayo.Ngaphezu kwalokho, izakhiwo ze-NAD ze-neuroprotective zingasiza ukuvimbela lo monakalo kwasekuqaleni.
Isikhathi sokuthumela: Sep-21-2023