What Is S-4 (Andrarine)

I-S-4, imakethwe njengei-andarine, i-oral bioavailable, non-steroidal selective androgen receptor modulator (SARM).I-Andarine iyi-agonist eyingxenye ye-androgen receptor.

I-S-4 njengamanye ama-SARMS athuthukiswa ekuqaleni kwe-2000s, emzamweni wokunqoba imikhawulo ye-pharmacologic kanye ne-pharmacokinetic ye-steroidal androgen receptor agonists (okungukuthi, i-testosterone ne-DHT), eye yaba izinhlangano ezaziwayo nesibindi nesifo senhliziyo.

I-Compound S-4 yasetshenziswa ezifundweni zezilwane kodwa yayekwa ngaphambi kwanoma yiziphi izivivinyo zomtholampilo zabantu zeSigaba I, ngenxa yokukhubazeka kokubona.Le miphumela kwenzeka njengoba i-molecule ye-S-4 ibophezela kuma-receptors esweni;lapho ukubopha kunamandla, yilapho kutholakala khona ukungakhululeki.Ukuphazamiseka okubukwayo kutholakale ukuthi kuvame kakhulu, ngenxa yesenzo esiyingqayizivele somshini, somuthi kangangokuthi izinhlolo ziye zayekwa.

Kwenza KanjaniS4Umsebenzi we-Andarine

Enye yezindlela eziphakanyisiwe zeS4, ukuthi ivimba ngokuphelele ukuboshwa kwe-DHT.I-Dihydrotestosterone (i-DHT, i-5α-dihydrotestosterone, i-5α-DHT, i-androstanolone noma i-stanolone) iyi-hormone yocansi ye-androgen engapheli.Ngokuphathelene ne-testosterone, i-DHT inamandla kakhulu njenge-agonist ye-androgen receptor.

I-S-4 ine-androgen receptor (AR) ephezulu ebophayo ebophayo.Ucwaningo luye lwabonisa ukuthi i-S-4 inamandla amancane futhi iyasebenza kune-testosterone propionate (TP) emsebenzini we-androgenic, kodwa umsebenzi wabo we-anabolic wawufana noma mkhulu kunowe-TP.

I-S-4 iyi-agonist egcwele ye-androgen receptor ezicutshini zemisipha, kanye ne-agonist ingxenye ku-prostate.Ngakho, i-S-4 ikhuthaza ngamandla ukukhula kwemisipha, kodwa ayikwazi ukugcina usayizi we-prostate.I-Testosterone ivuselela ukukhula kwemisipha ne-prostate ngezinga elifanayo.I-S-4 idala i-hormone ye-luteinizing ephawulekayo (LH) noma ukucindezelwa kwe-hormone evuselela i-follicle.

I-S-4 (i-andarine) Izinzuzo

Nakuba ucwaningo oluningi lwenziwe, ucwaningo olwengeziwe lusaqhubeka futhi ezigabeni zokuqala zokuthuthuka.Ukuthuthukiswa kwe-SARMS yokusetshenziswa komtholampilo kanye nokwelapha njengendlela ehlukile ye-androgen, kuyathembisa ngokusekelwe kudatha ye-preclinical.

Ngokungafani nama-anabolic steroids, abophezela kuma-androgen receptors ezicutshini eziningi kuwo wonke umzimba, ama-SARM ngamanye abopha ngokukhetha kuma-androgen receptors ezicutshini ezithile, kodwa hhayi kwabanye.Noma kunjalo, basabonisa imiphumela ye-androgenic ne-anabolic.

Ama-SARMS awawona ama-anabolic steroid;kunalokho, zingama-synthetic ligands abopha kuma-androgen receptors.Ngokuya ngesakhiwo sabo samangqamuzana, basebenza njengama-agonists, ama-agonists ayingxenye, nabaphikisi.Ngakho-ke, ngendlela ekhethiwe, ukuthi i-SARMS iguqule noma ixhumanise ama-coregulators kanye nezici zokuloba noma ukusayina amaprotheni e-cascade ukukhuthaza umsebenzi we-anabolic.

Ucwaningo luye lwabonisa ukuthi i-S-4 iyi-agonist egcwele ye-androgen receptor ezicutshini zemisipha, kanye ne-agonist ingxenye ku-prostate, okuyenza ibe ikhandidethi efanelekile njengenye indlela yama-steroidal androgen receptor agonists (okungukuthi, i-testosterone ne-DHT), ngenxa yemiphumela emibi ehlobene nayo. esibindini, enhliziyweni, nasekuvundeni.

Kumele kuqashelwe, ukuthi nakuba ama-SARMS afana ne-S4 akhulisa umsebenzi we-androgen, akuyona ikhandidethi esebenzayo yokwelapha i-hormone esikhundleni, ngoba ayifaki i-Estrogen.